Reactive oxygen species and nitric oxide in viral diseases
Identifieur interne : 001B72 ( Main/Exploration ); précédent : 001B71; suivant : 001B73Reactive oxygen species and nitric oxide in viral diseases
Auteurs : Ernst Peterhans [Suisse]Source :
- Biological Trace Element Research [ 0163-4984 ] ; 1997-01-01.
English descriptors
- KwdEn :
Abstract
Abstract: Metabolites derived from superoxide (o2 •−) and nitric oxide (NO•) play an important role in antimicrobial and antitumoral defense, but may also harm the host. Low levels of such metabolites can also facilitate viral replication because of their mitogenic effects on cells. Most viruses grow better in proliferating cells, and indeed, many viruses induced in their host cell changes similar to those seen early after treatment with mitogenic lectins. Influenza and paramyxoviruses activate in phagocytes the generation of superoxide by a mechanism involving the interaction between the viral surface glycoproteins and the phagocyte’s plasma membrane. Interestingly, viruses that activate this host defense mechanism are toxic when injected in the bloodstream of animals. Mice infected with influenza virus undergo oxidative stress. In addition, a wide array of cytokines are formed in the lung, contributing to the systemic effects of influenza. Oxidative stress is seen also in chronic viral infections, such as AIDS and viral hepatitis. Oxidant production in viral hepatitis may contribute to the emergence of hepatocellular carcinoma, a tumor seen in patients after years of chronic inflammation of the liver. Antioxidants and agents that downregulate proinflammatory cytokines and lipid mediators may be a useful complement to specific antiviral drugs in the therapy of viral diseases.
Url:
DOI: 10.1007/BF02778986
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000826
- to stream Istex, to step Curation: 000826
- to stream Istex, to step Checkpoint: 000958
- to stream Main, to step Merge: 001C34
- to stream Main, to step Curation: 001B72
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Reactive oxygen species and nitric oxide in viral diseases</title><author><name sortKey="Peterhans, Ernst" sort="Peterhans, Ernst" uniqKey="Peterhans E" first="Ernst" last="Peterhans">Ernst Peterhans</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:A206DFEB93D11FFEA4B014851CB1E1C5D158D643</idno><date when="1997" year="1997">1997</date><idno type="doi">10.1007/BF02778986</idno><idno type="url">https://api.istex.fr/ark:/67375/VQC-0R0X67KP-F/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000826</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000826</idno><idno type="wicri:Area/Istex/Curation">000826</idno><idno type="wicri:Area/Istex/Checkpoint">000958</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000958</idno><idno type="wicri:doubleKey">0163-4984:1997:Peterhans E:reactive:oxygen:species</idno><idno type="wicri:Area/Main/Merge">001C34</idno><idno type="wicri:Area/Main/Curation">001B72</idno><idno type="wicri:Area/Main/Exploration">001B72</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Reactive oxygen species and nitric oxide in viral diseases</title><author><name sortKey="Peterhans, Ernst" sort="Peterhans, Ernst" uniqKey="Peterhans E" first="Ernst" last="Peterhans">Ernst Peterhans</name><affiliation wicri:level="3"><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Veterinary Virology, University of Berne, CH-3012, Berne</wicri:regionArea><placeName><settlement type="city">Berne</settlement><region type="région" nuts="3">Canton de Berne</region></placeName></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Suisse</country></affiliation></author></analytic><monogr></monogr><series><title level="j">Biological Trace Element Research</title><title level="j" type="abbrev">Biol Trace Elem Res</title><idno type="ISSN">0163-4984</idno><idno type="eISSN">1559-0720</idno><imprint><publisher>Humana Press</publisher><pubPlace>Totowa</pubPlace><date type="published" when="1997-01-01">1997-01-01</date><biblScope unit="volume">56</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="107">107</biblScope><biblScope unit="page" to="116">116</biblScope></imprint><idno type="ISSN">0163-4984</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0163-4984</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>HIV</term><term>Virus</term><term>antioxidants</term><term>cytokines</term><term>hepatitis</term><term>influenza</term><term>metabolism</term><term>nitric oxide</term><term>physiology</term><term>therapy</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Metabolites derived from superoxide (o2 •−) and nitric oxide (NO•) play an important role in antimicrobial and antitumoral defense, but may also harm the host. Low levels of such metabolites can also facilitate viral replication because of their mitogenic effects on cells. Most viruses grow better in proliferating cells, and indeed, many viruses induced in their host cell changes similar to those seen early after treatment with mitogenic lectins. Influenza and paramyxoviruses activate in phagocytes the generation of superoxide by a mechanism involving the interaction between the viral surface glycoproteins and the phagocyte’s plasma membrane. Interestingly, viruses that activate this host defense mechanism are toxic when injected in the bloodstream of animals. Mice infected with influenza virus undergo oxidative stress. In addition, a wide array of cytokines are formed in the lung, contributing to the systemic effects of influenza. Oxidative stress is seen also in chronic viral infections, such as AIDS and viral hepatitis. Oxidant production in viral hepatitis may contribute to the emergence of hepatocellular carcinoma, a tumor seen in patients after years of chronic inflammation of the liver. Antioxidants and agents that downregulate proinflammatory cytokines and lipid mediators may be a useful complement to specific antiviral drugs in the therapy of viral diseases.</div></front></TEI><affiliations><list><country><li>Suisse</li></country><region><li>Canton de Berne</li></region><settlement><li>Berne</li></settlement></list><tree><country name="Suisse"><region name="Canton de Berne"><name sortKey="Peterhans, Ernst" sort="Peterhans, Ernst" uniqKey="Peterhans E" first="Ernst" last="Peterhans">Ernst Peterhans</name></region><name sortKey="Peterhans, Ernst" sort="Peterhans, Ernst" uniqKey="Peterhans E" first="Ernst" last="Peterhans">Ernst Peterhans</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001B72 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001B72 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= H2N2V1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:A206DFEB93D11FFEA4B014851CB1E1C5D158D643
|texte= Reactive oxygen species and nitric oxide in viral diseases
}}
| This area was generated with Dilib version V0.6.33. |  |